Steps in Intrinsic pathway of apoptosis

 Intrinsic pathway of Apoptosis

• Severe DNA damage signals for increase in Bax/Bak dimers.

• Bax/Bak dimers form channel on mitochondrial membrane.

• Cytochrome c escape from these channels out of mitochondria.

• In the cytosol cytochrome c bind to apaf and activate them by a conformation change.

• Activated Apaf1 assembled into Heptamer.

• It now bind to initiaitor caspases ie. Procaspases 9.

• Activated caspases 9 activate executioner caspapses(3)